תיאור
What is trazodone?
Trazodone belongs to a group of drugs called SARI – That means Serotonin Antagonist and Reuptake Inhibitor. It acts on the central nervous system and affects brain chemicals related to mood, especially Serotonin, a substance that affects feelings of calm, sleep, and emotional balance.
Unlike drugs from the SSRI or SNRI groups, trazodone combines the action of mild inhibition of serotonin reuptake along with an effect on additional receptors – which explains its dual effect: both Improving mood also Sleep soaking.
Main uses
Trazodone is usually given in the following situations:
-
Clinical depression (Major Depressive Disorder)
-
Generalized anxiety or anxiety associated with depression
-
Sleep disorders, especially when there is also a background of depression or mental stress
-
Supportive treatment for states of restlessness, chronic fatigue, or decreased motivation
There are cases in which trazodone is also given "off-label" (that is, not according to the official instructions) - for example, in cases of attention deficit disorder with an emotional component, or as a substitute for sedatives that are more addictive.
Commercial forms in Israel
| Name of the medicine | Active ingredient | manufacturer | Form of administration |
|---|---|---|---|
| Trazodil (Trezodil) | Trazodone Hydrochloride | Rekadot | Tablets |
| Triptych (Tritico) | Trazodone Hydrochloride | Angelini | XR (extended-release) tablets |
Dosages and method of use
Treatment usually begins with a low dose, which can be gradually increased according to the patient's needs and reactions:
-
Starting dose: 50–100 mg per day, before bedtime
-
Therapeutic dose for depression: Up to 300 mg per day (in divided doses)
-
Maximum dose in hospital: Up to 600 mg per day (under medical supervision)
Usage instructions:
-
It is recommended to take the medication in the evening due to its calming effect.
-
Can be taken with or without food; eating a light meal reduces nausea.
-
Duration of effect: 4–8 hours.
-
An effect on sleep will usually be felt within a few days. The antidepressant effect will usually be felt within 2–4 weeks.
Side effects
Like any medication, trazodone can have side effects. Many of them are mild and temporary:
Common symptoms:
-
Fatigue, drowsiness
-
Dizziness, drop in blood pressure when changing position
-
Dry mouth
-
Headaches
-
Nausea or stomach discomfort
Rare and important phenomena:
-
Trazodone 100mg Change in heart rate (QT prolongation)
-
Decreased libido or changes in sexual function
-
A rare phenomenon called priapism (prolonged erection without sexual stimulation) – requires immediate medical treatment
-
Confusion or mental fogginess, especially in the elderly
⚠️ Consult a doctor in cases of unusual symptoms, worsening mood, suicidal thoughts, or new physical symptoms.
When should you not use trazodone?
-
Known sensitivity to trazodone or any other component of the drug
-
Concomitant use of MAOI drugs (or within 14 days of discontinuing them)
-
History of severe cardiac arrhythmias or QT prolongation
-
Severe liver disease
-
Pregnancy and breastfeeding – only with a doctor’s approval
Interactions with other drugs
Trazodone may create dangerous reactions with other drugs or substances, so it is important to inform your doctor about any medications you are taking:
Combinations to watch out for:
-
Other antidepressants (SSRI, SNRI, MAOI)
-
Medications for sleep or anxiety (benzodiazepines)
-
Anticonvulsant medications
-
Alcohol – increases the risk of dizziness, confusion, and excessive deep sleep
Advantages of trazodone compared to other medications
| drug | Impact time | Key advantage |
|---|---|---|
| Trazodone | 4–8 hours | Combines sleep and mood improvement |
| Sertraline | 24 hours | Emotional stability throughout the day |
| Mirtazapine | 20–30 hours | Increases appetite, suitable for weight loss situations |
| Escitalopram | 24 hours | Minimal side effects for the most part |
Frequently Asked Questions (FAQ)
1. Is Trazodone addictive?
No, the drug does not cause physical dependence like benzodiazepines, but it should be discontinued gradually and not all at once.
2. Can it be used only to improve sleep?
Yes, sometimes doctors recommend a low dose just to improve sleep, but it is important to evaluate the overall clinical picture.
3. When do you feel improvement?
In sleep – within a few days. In depression – usually after two to three weeks. Full effect is possible after 4–6 weeks.
4. Is it allowed to combine with other medications for depression?
Sometimes yes, but only under close medical supervision due to fear of interactions such as serotonin syndrome.
Quick technical information
| Characteristic | Detail |
|---|---|
| Generic name | Trazodone |
| group | SARI (serotonin reuptake inhibitor + serotonin antagonist) |
| Initial response time | 30–60 minutes |
| Frequency of taking | Usually once a day in the evening |
| Formations | Regular or extended-release (XR) tablets |
| Marketing in Israel | Trazodil, Tritico |
In conclusion
Trazodone is a well-established, reliable drug with a well-known safety profile. It is suitable for patients suffering from depression with features of anxiety or insomnia, and sometimes constitutes a gentler alternative to strong or addictive antidepressants. As with any drug treatment, it should be tailored to your individual situation after professional medical advice.
clarification: This content does not constitute medical advice. Do not start or stop medication without consulting a doctor.
Asa –
Professional and courteous service – definitely worth ordering again. Surprised by the high availability – there is always a response, without unnecessary waiting.
Ilai –
A very positive experience. Everything went smoothly, and the service included great discounts for ordering several packages together – saves a lot.
Hiley –
No prescription is required, and the product arrived very quickly. Ordering is done without the need for a prescription at all – an easy and quick process.
Danil –
One of the most convenient sites I've come across. I was surprised by the high availability – there's always a response, without unnecessary waiting.
Neo –
Within minutes of ordering, I received confirmation and everything progressed quickly.
knight –
Even when there was a question – they answered it instantly via chat. Customer service is truly available.
glory –
No prescription is required, and the product arrived very quickly. No need to mess with a prescription – just order and receive.
Milo –
There's no need to get complicated, everything is clear and convenient. There are lucrative discounts for ordering several packages together - saves a lot.
Eliezer –
The shipment arrived even ahead of schedule. Everything was clear and organized.
Vineyards –
Everything was delivered on time, including support via apps. Ordering is done without the need for a prescription at all – an easy and quick process.
Milan –
A very positive experience. Everything went smoothly, and the service included the service also operating on Saturday, which makes it very easy when you need an urgent response.
Annan –
The order was simple and convenient, with an extremely fast response. The order was delivered in a sealed and original package, just as expected from a professional place.
Adi-Li –
A very positive experience. Everything went smoothly, and the service also included the option to pay in Bitcoin – an innovative and efficient solution for those who prefer.
Mikey –
Professional and courteous service – definitely worth ordering again. The selection on the site is impressive – a large variety of products available for immediate delivery.
Issa –
No prescription is required, and the product arrived very quickly. You can also order via WhatsApp or Telegram – convenient, fast, and always available.
pigeon –
An experience on a different level. You can get used to it easily.
Timur –
No prescription was required, and the product arrived very quickly. I was surprised by the high availability – there is always a response, without unnecessary waiting.
Narcissus –
Extremely fast delivery, easy-to-use website, and excellent service. The order was delivered in a sealed, original package, just as expected from a professional place.
Charlie –
Professional and courteous service – definitely worth ordering again. The service also operates on Saturdays, which makes it very easy when you need an urgent response.
comet –
The order was processed quickly, with full availability and a quick response. You can also order via WhatsApp or Telegram – convenient, fast and always available.
Yinon –
Kudos to the team – fast, professional, and gives a sense of security.
Iten –
Professional and courteous service – definitely worth ordering again. Extremely quick response, even late in the evening.
Abyada –
No prescription is required, and the product arrived very quickly. The selection on the site is impressive – a large variety of products available for immediate delivery.
Israel –
One of the most convenient sites I've come across. There is an option to pay in cash, which adds great convenience to the process.
Planted –
One of the most convenient sites I've come across. Ordering is done without the need for a registration at all - an easy and quick process.
Rani –
Chat response within seconds, simple ordering process. You can also order via WhatsApp or Telegram – convenient, fast and always available.
gentle –
Extremely fast delivery, easy-to-use website, and excellent service. No need to mess with a prescription – just order and receive.
Eliran –
The order was simple and convenient, with an extremely fast response. I was surprised by the high availability – there is always a response, without unnecessary waiting.
rich –
Professional and courteous service – definitely worth ordering again. There is an option to pay in cash, which adds great convenience to the process.
other –
The service was exceptional – both fast and available at any time. There are great discounts for ordering several packages together – saves a lot.
Yehosef –
No prescription is required, and the product arrived very quickly. The service reaches every region in the country, even relatively remote places.
גאל –
Chat response within seconds, simple ordering process. Extremely fast response, even late in the evening.
given –
The order was processed quickly, with full availability and a quick response. Convenient option for payment with a withdrawal code – no credit card required.
From Michal –
A very positive experience. Everything went smoothly, and the service also included a convenient option for payment by debit card – no credit card required.
Job –
Everything was provided on time, including support via apps. Responses were extremely fast, even late in the evening.
Jackie –
A very positive experience. Everything went smoothly, and the service in general was also surprised by the high availability – there is always a response, without unnecessary waiting.
Above –
No prescription is required, and the product arrived very quickly. There are attractive discounts for ordering several packages together – saves a lot.
broom –
Chat response within seconds, simple ordering process. Cash payment is available, which adds great convenience to the process.
Leon –
There is no need to get complicated, everything is clear and convenient. Ordering is done without the need for a prescription at all – an easy and quick process.
rummy –
It seems like this is a team that understands the subject. Everything was just accurate.
Zippy –
Chat response within seconds, simple ordering process. You can also pay in Bitcoin – an innovative and efficient solution for those who prefer.
Orad –
A simple and pleasant interface, customer service that responded quickly, and everything worked smoothly.
ראובן –
Professional and courteous service – definitely worth ordering again. Ordering is done without the need for a prescription at all – an easy and quick process.
Isaiah –
No need to get complicated, everything is clear and convenient. You can also order via WhatsApp or Telegram – convenient, fast and always available.
יהורם –
No prescription was required, and the product arrived very quickly. An extremely quick response was received, even late in the evening.
Dylan –
Excellent purchasing experience. Everything went smoothly, with available and supportive customer service.
Galilee –
No prescription is required, and the product arrived very quickly. There is an option to pay in cash, which adds great convenience to the process.
maximum –
No prescription is required, and the product arrived very quickly. You can also pay in Bitcoin – an innovative and efficient solution for those who prefer.
Abigail –
One of the most convenient sites I've come across. Convenient option for payment with a withdrawal code... without the need for a credit card.
My friends –
Extremely fast delivery, easy-to-use website, and excellent service. The service also operates on Saturdays, which makes it very easy when you need an urgent response.
Praise –
No prescription required, and the product arrived very quickly. Convenient option for payment by debit card – no credit card required.
Gary –
Ordering was simple and convenient, with an extremely fast response. The selection on the site is impressive – a large variety of products available for immediate delivery.
Hamza –
There aren't many places with service like this. They answer in chat within seconds!
אורן –
Chat response within seconds, simple ordering process. Surprised by the high availability – there is always a response, without unnecessary waiting.
wilting –
Professional and courteous service – definitely worth ordering again. The service reaches every region of the country, even relatively remote places.
ארין –
The order was simple and convenient, with an extremely fast response. No need to mess with a prescription – just order and receive.
יניב-משה –
A very positive experience. Everything went smoothly, and the service also included the option to pay in cash, which adds great convenience to the process.