{"id":24564,"date":"2025-06-27T00:40:06","date_gmt":"2025-06-27T00:40:06","guid":{"rendered":"http:\/\/zebra.pp.ua\/stripes\/?p=24564"},"modified":"2026-04-16T23:45:57","modified_gmt":"2026-04-16T23:45:57","slug":"%d7%9e%d7%a1%d7%99%d7%a8-mesyrel-trazodone","status":"publish","type":"product","link":"http:\/\/www.pharmacare.co.il\/en\/trazodone\/","title":{"rendered":"Trazodone"},"content":{"rendered":"

What is trazodone?<\/h2>\n

Trazodone belongs to a group of drugs called SARI<\/strong> \u2013 That means Serotonin Antagonist and Reuptake Inhibitor. It acts on the central nervous system and affects brain chemicals related to mood, especially Serotonin<\/strong>, a substance that affects feelings of calm, sleep, and emotional balance.<\/p>\n

Unlike drugs from the SSRI or SNRI groups, trazodone combines the action of mild inhibition of serotonin reuptake along with an effect on additional receptors \u2013 which explains its dual effect: both Improving mood<\/strong> also Sleep soaking<\/strong>.<\/p>\n

\n

Main uses<\/h2>\n

Trazodone is usually given in the following situations:<\/p>\n

    \n
  • \n

    Clinical depression<\/strong> (Major Depressive Disorder)<\/p>\n<\/li>\n

  • \n

    Generalized anxiety or anxiety associated with depression<\/strong><\/p>\n<\/li>\n

  • \n

    Sleep disorders<\/strong>, especially when there is also a background of depression or mental stress<\/p>\n<\/li>\n

  • \n

    Supportive treatment for states of restlessness, chronic fatigue, or decreased motivation<\/strong><\/p>\n<\/li>\n<\/ul>\n

    There are cases in which trazodone is also given "off-label" (that is, not according to the official instructions) - for example, in cases of attention deficit disorder with an emotional component, or as a substitute for sedatives that are more addictive.<\/p>\n

    \n

    Commercial forms in Israel<\/h2>\n
    \n
    \n\n\n\n\n\n\n
    Name of the medicine<\/th>\nActive ingredient<\/th>\nmanufacturer<\/th>\nForm of administration<\/th>\n<\/tr>\n<\/thead>\n
    Trazodil<\/strong> (Trezodil)<\/td>\nTrazodone Hydrochloride<\/td>\nRekadot<\/td>\nTablets<\/td>\n<\/tr>\n
    Triptych<\/strong> (Tritico)<\/td>\nTrazodone Hydrochloride<\/td>\nAngelini<\/td>\nXR (extended-release) tablets<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
    <\/div>\n<\/div>\n<\/div>\n<\/div>\n
    \n

    Dosages and method of use<\/h2>\n

    Treatment usually begins with a low dose, which can be gradually increased according to the patient's needs and reactions:<\/p>\n

      \n
    • \n

      Starting dose<\/strong>: 50\u2013100 mg per day, before bedtime<\/p>\n<\/li>\n

    • \n

      Therapeutic dose for depression<\/strong>: Up to 300 mg per day (in divided doses)<\/p>\n<\/li>\n

    • \n

      Maximum dose in hospital<\/strong>: Up to 600 mg per day (under medical supervision)<\/p>\n<\/li>\n<\/ul>\n

      Usage instructions:<\/h3>\n
        \n
      • \n

        It is recommended to take the medication in the evening due to its calming effect.<\/p>\n<\/li>\n

      • \n

        Can be taken with or without food; eating a light meal reduces nausea.<\/p>\n<\/li>\n

      • \n

        Duration of effect: 4\u20138 hours.<\/p>\n<\/li>\n

      • \n

        An effect on sleep will usually be felt within a few days. The antidepressant effect will usually be felt within 2\u20134 weeks.<\/p>\n<\/li>\n<\/ul>\n

        \n

        Side effects<\/h2>\n

        Like any medication, trazodone can have side effects. Many of them are mild and temporary:<\/p>\n

        Common symptoms:<\/h3>\n
          \n
        • \n

          Fatigue, drowsiness<\/p>\n<\/li>\n

        • \n

          Dizziness, drop in blood pressure when changing position<\/p>\n<\/li>\n

        • \n

          Dry mouth<\/p>\n<\/li>\n

        • \n

          Headaches<\/p>\n<\/li>\n

        • \n

          Nausea or stomach discomfort<\/p>\n<\/li>\n<\/ul>\n

          Rare and important phenomena:<\/h3>\n
            \n
          • \n
            \n \"\u05d8\u05e8\u05d6\u05d5\u05d3\u05d5\u05df
            Trazodone 100mg <\/figcaption><\/figure>\n<\/figure>\n

            Change in heart rate (QT prolongation)<\/p>\n<\/li>\n

          • \n

            Decreased libido or changes in sexual function<\/p>\n<\/li>\n

          • \n

            A rare phenomenon called priapism (prolonged erection without sexual stimulation) \u2013 requires immediate medical treatment<\/p>\n<\/li>\n

          • \n

            Confusion or mental fogginess, especially in the elderly<\/p>\n<\/li>\n<\/ul>\n

            \u26a0\ufe0f Consult a doctor in cases of unusual symptoms, worsening mood, suicidal thoughts, or new physical symptoms.<\/p>\n

            \n

            When should you not use trazodone?<\/h2>\n
              \n
            • \n

              Known sensitivity to trazodone or any other component of the drug<\/p>\n<\/li>\n

            • \n

              Concomitant use of MAOI drugs (or within 14 days of discontinuing them)<\/p>\n<\/li>\n

            • \n

              History of severe cardiac arrhythmias or QT prolongation<\/p>\n<\/li>\n

            • \n

              Severe liver disease<\/p>\n<\/li>\n

            • \n

              Pregnancy and breastfeeding \u2013 only with a doctor\u2019s approval<\/p>\n<\/li>\n<\/ul>\n

              \n

              Interactions with other drugs<\/h2>\n

              Trazodone may create dangerous reactions with other drugs or substances, so it is important to inform your doctor about any medications you are taking:<\/p>\n

              Combinations to watch out for:<\/h3>\n
                \n
              • \n

                Other antidepressants (SSRI, SNRI, MAOI)<\/p>\n<\/li>\n

              • \n

                Medications for sleep or anxiety (benzodiazepines)<\/p>\n<\/li>\n

              • \n

                Anticonvulsant medications<\/p>\n<\/li>\n

              • \n

                Alcohol \u2013 increases the risk of dizziness, confusion, and excessive deep sleep<\/p>\n<\/li>\n<\/ul>\n

                \n

                Advantages of trazodone compared to other medications<\/h2>\n
                \n
                \n\n\n\n\n\n\n\n\n
                drug<\/th>\nImpact time<\/th>\nKey advantage<\/th>\n<\/tr>\n<\/thead>\n
                Trazodone<\/td>\n4\u20138 hours<\/td>\nCombines sleep and mood improvement<\/td>\n<\/tr>\n
                Sertraline<\/td>\n24 hours<\/td>\nEmotional stability throughout the day<\/td>\n<\/tr>\n
                Mirtazapine<\/td>\n20\u201330 hours<\/td>\nIncreases appetite, suitable for weight loss situations<\/td>\n<\/tr>\n
                Escitalopram<\/td>\n24 hours<\/td>\nMinimal side effects for the most part<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
                \n
                <\/div>\n<\/div>\n<\/div>\n<\/div>\n
                \n

                Frequently Asked Questions (FAQ)<\/h2>\n

                1. Is Trazodone addictive?<\/strong>
                No, the drug does not cause physical dependence like benzodiazepines, but it should be discontinued gradually and not all at once.<\/p>\n

                2. Can it be used only to improve sleep?<\/strong>
                Yes, sometimes doctors recommend a low dose just to improve sleep, but it is important to evaluate the overall clinical picture.<\/p>\n

                3. When do you feel improvement?<\/strong>
                In sleep \u2013 within a few days. In depression \u2013 usually after two to three weeks. Full effect is possible after 4\u20136 weeks.<\/p>\n

                4. Is it allowed to combine with other medications for depression?<\/strong>
                Sometimes yes, but only under close medical supervision due to fear of interactions such as serotonin syndrome.<\/p>\n

                \n

                Quick technical information<\/h2>\n
                \n
                \n\n\n\n\n\n\n\n\n\n\n
                Characteristic<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
                Generic name<\/td>\nTrazodone<\/td>\n<\/tr>\n
                group<\/td>\nSARI (serotonin reuptake inhibitor + serotonin antagonist)<\/td>\n<\/tr>\n
                Initial response time<\/td>\n30\u201360 minutes<\/td>\n<\/tr>\n
                Frequency of taking<\/td>\nUsually once a day in the evening<\/td>\n<\/tr>\n
                Formations<\/td>\nRegular or extended-release (XR) tablets<\/td>\n<\/tr>\n
                Marketing in Israel<\/td>\nTrazodil, Tritico<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
                \n
                <\/div>\n<\/div>\n<\/div>\n<\/div>\n
                \n

                In conclusion<\/h2>\n

                Trazodone is a well-established, reliable drug with a well-known safety profile. It is suitable for patients suffering from depression with features of anxiety or insomnia, and sometimes constitutes a gentler alternative to strong or addictive antidepressants. As with any drug treatment, it should be tailored to your individual situation after professional medical advice.<\/p>\n

                \n

                clarification:<\/strong> This content does not constitute medical advice. Do not start or stop medication without consulting a doctor.<\/p>","protected":false},"excerpt":{"rendered":"

                Trazodone dosages available in stock:<\/h2>\n
                  \n
                • \n

                  Trazodone 50 mg<\/span><\/p>\n<\/li>\n

                • \n

                  Trazodone 100 mg<\/span><\/p>\n<\/li>\n

                • \n

                  Trazodone 150 mg<\/span><\/p>\n<\/li>\n

                • \n

                  Trazodone 300 mg<\/span><\/p>\n<\/li>\n<\/ul>","protected":false},"featured_media":25227,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_cat":[33],"product_tag":[],"class_list":{"0":"post-24564","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-depression-anxiety","8":"first","9":"instock","10":"shipping-taxable","11":"product-type-simple"},"yoast_head":"\n\u05d8\u05e8\u05d6\u05d5\u05d3\u05d5\u05df (Trazodone) \u05dc\u05de\u05db\u05d9\u05e8\u05d4 | \u05dc\u05dc\u05d0 \u05e4\u05e8\u05d5\u05e6\u05d3\u05d5\u05e8\u05d4 | \u05de\u05e9\u05dc\u05d5\u05d7 \u05de\u05d4\u05d9\u05e8 \u05e2\u05d3 \u05d4\u05d1\u05d9\u05ea<\/title>\n<meta name=\"description\" content=\"\u05d8\u05e8\u05d6\u05d5\u05d3\u05d5\u05df (Trazodone) \u05dc\u05d8\u05d9\u05e4\u05d5\u05dc \u05d1\u05d3\u05d9\u05db\u05d0\u05d5\u05df \u05d5\u05e0\u05d3\u05d5\u05d3\u05d9 \u05e9\u05d9\u05e0\u05d4. \u05e4\u05ea\u05e8\u05d5\u05df \u05d9\u05e2\u05d9\u05dc \u05dc\u05d4\u05e8\u05d2\u05e2\u05d4 \u05d5\u05e9\u05d9\u05e0\u05d4 \u05d8\u05d5\u05d1\u05d4. \u05d4\u05d6\u05de\u05d9\u05e0\u05d5 \u05d0\u05d5\u05e0\u05dc\u05d9\u05d9\u05df \u05d5\u05e7\u05d1\u05dc\u05d5 \u05de\u05e9\u05dc\u05d5\u05d7 \u05de\u05d4\u05d9\u05e8 \u05e2\u05d3 \u05d4\u05d1\u05d9\u05ea. \u05dc\u05d1\u05d3\u05d9\u05e7\u05ea \u05de\u05d7\u05d9\u05e8 \u05dc\u05d7\u05e6\u05d5 \u05db\u05d0\u05df.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pharmacare.co.il\/en\/trazodone\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u05d8\u05e8\u05d6\u05d5\u05d3\u05d5\u05df (Trazodone)\" \/>\n<meta property=\"og:description\" content=\"\u05d8\u05e8\u05d6\u05d5\u05d3\u05d5\u05df (Trazodone) \u05dc\u05d8\u05d9\u05e4\u05d5\u05dc 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