Arcoxia (Etoricoxib): The complete guide to pain and inflammation relief – dosages (60, 90, 120 mg), side effects, and is it safe to use?

Arcoxia, also known as Etoricoxib, is a drug that belongs to the COX-2 enzyme inhibitor family. This family is included in the group of NSAIDs (non-steroidal anti-inflammatory drugs). Its main purpose is to relieve pain and reduce inflammatory processes. Many ask whether Arcoxia is dangerous, whether Arcoxia is stronger compared to other drugs, and whether long-term use is safe. In this guide, we will review all aspects related to the drug: from the mechanism of action and benefits, through the different doses (60, 90, 120 mg) to the side effects and warnings. We will also examine Arcoxia compared to other drugs such as Celebrex and Etopan. Finally, we will answer frequently asked questions including whether Arcoxia reduces fever, whether Arcoxia causes constipation, and how Arcoxia interacts with other drugs.

General background: What is Arcoxia (Etoricoxib)?

Arcoxia is a common brand name for the drug Etoricoxib. It is considered part of the selective COX-2 inhibitor class. These drugs are used to treat pain and inflammation, but they are slightly different from other NSAIDs (such as ibuprofen and naproxen).

COX-2 inhibitors: mechanism of action

COX-1 and COX-2 enzymes regulate the production of pain and inflammation mediators, called prostaglandins. Non-selective NSAIDs (such as ibuprofen) block both enzymes, thus reducing pain and inflammation. However, they may also have a greater effect on the digestive system. Arcoxia (Etoricoxib) specifically targets the COX-2 enzyme, thereby reducing side effects related to damage to the stomach lining and bleeding. As a result, pain relief is possible without significantly impairing the stomach's natural defense mechanisms.

Benefits of using Arcoxia

1. Targeted impact: Targets COX-2 and less so COX-1.
2. Less impact on the digestive system: Compared to classic NSAIDs, the risk of stomach ulcers and bleeding is lower.
3. Effective treatment of various pains: Including joint pain, back pain and even toothache.

However, it is worth remembering that high selectivity for COX-2 may increase the risk of cardiovascular events (such as heart attacks). Therefore, it is important to follow your doctor's instructions and ensure that the medication is appropriate for your personal medical profile.

What is Arcoxia used for? (Main indications)

Arcoxia (Etoricoxib) is suitable for a variety of medical conditions related to pain and inflammation. Below is an explanation of the common scenarios in which the drug is used.

2.1 Treatment of acute and chronic pain

• Back pain: Many report relief while taking Arcoxia for back pain. The name “arcoxia for back pain” indicates its popularity in this area.
• Toothache: Sometimes used for cases of severe toothache, especially when there is inflammation of the gums. There is also reference to a 120 mg dose – “arcoxia 120 mg for toothache” – in severe cases, but a doctor’s recommendation is required.
• HeadachesArcoxia can help with headaches caused by muscle tension or mild inflammation of the jaw joints. However, it is not always the first choice for headaches.

2.2 Treatment of arthritis

• Osteoarthritis: Can be helpful in reducing pain and improving movement.
• Rheumatoid Arthritis: Reduces swelling and improves quality of life.
• Gout: Arcoxia is effective for acute gout inflammation. Research indicates its effectiveness in reducing pain and swelling. In these cases, careful medical judgment is required (arcoxia for gout).

2.3 Relieving menstrual pain

Some women use Arcoxia to relieve menstrual cramps. The drug has an anti-inflammatory effect that reduces the sensation of pain in the lower abdomen.

2.4 Additional indications

Some doctors recommend Etoricoxib for various other inflammatory conditions, in the context of orthopedic or neuropathic pain. Use in each case requires professional examination. Arcoxia is not always the ideal choice, but it is a very effective option in some cases.

Dosages and instructions for use: Arcoxia 60, 90, 120 mg

Arcoxia comes in several main doses: 60 mg, 90 mg, and 120 mg. The dosage depends on the type of medical problem, the intensity of the pain, and the patient's condition. It is important to follow the instructions of the treating physician and read the consumer leaflet carefully.

3.1 Arcoxia 60 mg

• Common uses:
  • Moderate osteoarthritis.
  • Mild to moderate pain in various situations.
• General guidelines:
  • Usually one tablet is taken per day.
  • It is worth paying attention to the body's reactions.
  • It is recommended to monitor for an increase in blood pressure or the appearance of other side effects.

3.2 Arcoxia 90 mg

• Why is this good?
  • Common for rheumatoid arthritis or more severe pain.
  • "arcoxia 90 mg uses" mainly indicates dealing with significant inflammatory conditions.
• Can it be taken long term?
  • Depends on the doctor's recommendation.
  • Some patients receive a long-term prescription, others take it for shorter periods of time.
• Arcoxia 90 side effects:
  • May be similar to the general side effects (we will expand on this in Part 4).
  • Changes in indicators such as blood pressure and kidney function should be monitored.

3.3 Arcoxia 120 mg

• Common uses:
  • Particularly acute conditions, such as gout (arcoxia for gout) or severe pain after dental procedures (arcoxia 120 mg for toothache).
  • Not recommended for long-term use due to increased risk of cardiovascular events.
• General guidelines:
  • Usually one tablet is taken per day, for a limited period of time.
  • It is important to consult your doctor regarding the duration of treatment.
• Arcoxia 60 side effects and Arcoxia 120 side effects:
  • The higher the dose, the higher the risk of serious side effects.

3.4 Is it possible to cross the Arcoxia hemisphere?

Many people ask, "Is Arcoxia half a pill?" or "Can I take half a tablet?" The answer depends on the specific form of the tablet. If the dividing line is present and approved in the leaflet, the pill can be divided. However, not every type of tablet has a suitable notch. In any case, you should consult a pharmacist or doctor before dividing, to ensure safety and uniformity of dosage.

3.5 Should I take it with or without food?

Arcoxia can usually be taken without food. However, some people prefer to take it with food to reduce gastrointestinal side effects. The packaging may state "Arcoxia to be taken with food" or "on an empty stomach". If there is a concern about digestive effects, taking it with a light meal may be helpful. It is recommended to read the official instructions (Arcoxia Instructions for Use) and consult a doctor.

3.6 How often can it be taken?

"Arcoxia how often?" This is an important question. The standard dosage is once a day (24 hours between doses). Overdosing on Arcoxia may increase the risk of side effects, such as very high blood pressure or kidney damage. Sometimes a proactive discontinuation will be required after a few days, especially at high doses of 120 mg. Therefore, you should follow your doctor's instructions and not take more than recommended.

3.7 How long does Arcoxia take to work?

Many report relief within one to two hours of taking it. The effect usually lasts for about 24 hours. Thus, a once-daily dose is required in most cases. However, the intensity of pain relief can vary from person to person. Sometimes the full effect will be felt after a few days of continuous use.

3.8 Arcoxia for children

In general, Arcoxia is not intended for children. Most studies and clinical experience relate to adults. Other NSAIDs are available for children (such as ibuprofen in appropriate doses). Therefore, any questions regarding “Arcoxia for children” should be consulted with a specialist pediatrician.

3.9 Arcoxia while driving

Most people do not experience any impairment in driving ability. However, some patients may feel dizzy or tired. Therefore, it is worth checking how the drug affects the body before driving or operating heavy equipment. The question "how long after Arcoxia is it allowed to drive" is individual. It is better to wait at least a few hours and make sure that dizziness or blurred vision does not appear.

Side effects of Arcoxia

Despite its effectiveness, Arcoxia may cause side effects. There are relatively common effects, along with rare but serious effects. Most often, the occurrence of side effects is related to the dosage, duration of treatment, and the patient's medical condition.

4.1 Common side effects

1. Abdominal pain and nausea: Some patients complain of abdominal discomfort. Sometimes heartburn or mild nausea occurs.
2. Dizziness: May occur when taking high doses or in combination with other medications.
3. Headaches: Headaches or a feeling of slight discomfort are sometimes reported.
4. Edema: Fluid retention can lead to swelling in the ankles or face.
5. Increased blood pressureCOX-2 inhibitors tend to raise blood pressure more than other NSAIDs.

4.2 More serious side effects

1. Cardiovascular events: There is a warning about an increased risk of heart attack or stroke, especially with prolonged use and high doses. Therefore, it is important to monitor for suspicious symptoms.
2. Kidney damage: Like most NSAIDs, Arcoxia may affect kidney function. People with kidney disease should inform their doctor before starting treatment.
3. Liver damage: In rare cases, Etoricoxib can affect liver enzymes. Periodic blood tests are recommended if use is prolonged.
4. Gastrointestinal bleeding: Although Arcoxia is considered safer for the stomach compared to non-selective drugs, it can still cause gastrointestinal bleeding, especially at high doses.

4.3 Is Arcoxia dangerous?

The question "Is Arcoxia dangerous" comes up often. The answer is complex. When the correct dosage is followed, it is usually safe to use in people without significant underlying diseases. However, it is not recommended for long-term treatment in patients with high cardiovascular risk or advanced liver and kidney diseases. You should adhere to your doctor's instructions and avoid independent changes in dosage.

4.4 Does Arcoxia cause constipation?

The drug is more known for causing nausea or diarrhea, and less for constipation. However, “Does Arcoxia cause constipation?” is a question that arises. There may be patients who report changes in bowel habits, including the possibility of constipation. The response varies from person to person, so any changes should be monitored.

4.5 Does Arcoxia cause fatigue?

Fatigue or a general feeling of weakness may occur, but they are not considered a particularly common phenomenon. If we notice that a persistent feeling of fatigue arises, we should consult our doctor. "Does Arcoxia cause fatigue?" - The answer is "possible", but it is not a major side effect.

4.6 Long-term side effects

Within the framework of "long-term Arcoxia side effects," the main concern is kidney damage, increased blood pressure, and increased risk of cardiovascular events. Therefore, it is important to check kidney function, monitor blood pressure, and consider the risk-benefit ratio before prolonged use.

4.7 Arcoxia Anxiety and Depression

There is no solid evidence that Etoricoxib directly causes anxiety or depression. However, some patients report minor mood swings. "Etoricoxib for depression" is not a topic on which there is much research information, but in any case of psychological change, it is recommended to inform the doctor.

Interactions with other drugs and alcohol

Arcoxia may affect the activity of other medications and vice versa. Also, combining it with alcohol requires caution.

5.1 Arcoxia and alcohol

Alcohol may increase some of the side effects of Arcoxia, such as the risk of gastrointestinal bleeding and liver damage. Excessive combination of alcohol with NSAIDs can be dangerous. Therefore, "Arcoxia and alcohol" is a combination that is recommended to be reduced or avoided. If you still consume alcohol in moderation, you should consult your doctor and pay attention to unusual symptoms.

5.2 Combination with blood thinners

Blood thinners (such as warfarin or other anticoagulants) increase the risk of bleeding, especially in the gastrointestinal tract. COX-2 inhibitors can also increase this risk, although less than other NSAIDs. Therefore, it is important to tell your doctor if you are taking blood thinners. Dosage adjustments or close monitoring may be necessary.

5.3 Combination with blood pressure medications and diuretics

COX-2 inhibitors, including Arcoxia, may reduce the effectiveness of blood pressure lowering medications and diuretics. Those taking these medications concurrently may notice a slight increase in blood pressure or edema. More frequent blood pressure monitoring is recommended.

5.4 Arcoxia and Optalgin

Some people ask, "Arcoxia and Optalgin - is it permissible to combine?" In general, it is sometimes possible to combine different painkillers for short periods. However, it is best to consult a doctor because any combination of medications may increase certain side effects (such as effects on the kidneys or liver). It is advisable not to take Optalgin and Arcoxia together for extended periods without medical supervision.

5.5 Arcoxia and antibiotics

Arcoxia is not considered an antibiotic. The question "Is Arcoxia an antibiotic?" is sometimes asked, but the answer is no. It is an anti-inflammatory and painkiller that does not affect bacteria. There is no principled prohibition against combining it with some types of antibiotics, but it is always recommended to inform the doctor about any concomitant medication.

5.6 Arcoxia in case of depression and anxiety

People taking antidepressants (e.g. selective serotonin reuptake inhibitors) should consult their doctor before combining Arcoxia. There is still a lack of specific information on significant interactions between Etoricoxib and psychiatric medications, but caution is always advisable.

Arcoxia vs. other medications (Celebrex, Atopen, Ibuprofen)

Most often, "arcoxia vs celebrex" comes up as a popular comparison. "Arcoxia or Atopen" is also a familiar question. We will present several important comparisons here.

6.1 Arcoxia vs. Celebrex

• Similar mechanism: Both are COX-2 inhibitor drugs.
• efficiency: Both are effective against pain and inflammation of the joints. The differences are mainly related to the individual side effect profile.
• Personal choiceCelebrex is more common in Israel, but Arcoxia may be suitable for people who did not respond well to Celebrex.

6.2 Arcoxia vs. Etopan

• Different family: Etopan is a trade name for Etodolac, which belongs to the non-selective, semi-selective, or partially selective NSAIDs.
• Overall efficiency: Both are effective for pain relief, but Atropine has a different side effect profile. Some patients suffer more digestive symptoms with Atropine than with Arcoxia.
• Choice based on the patient's medical condition: "Arcoxia or Atopen?" Depends on underlying diseases, medical history, and patient response.

6.3 Arcoxia vs. Ibuprofen

• Selectivity: Ibuprofen blocks both COX-1 and COX-2 to a similar extent, which may cause more stomach upset.
• Half-lifeArcoxia: It works for a longer time. Ibuprofen usually requires repeated doses throughout the day.
• Effect on the heart: Arcoxia, being selective for COX-2, is associated with slightly more cardiovascular risk compared to ibuprofen (dose-dependent).

6.4 Arcoxia vs Ibuprofen

Sometimes patients ask “arcoxia vs ibuprofen” in the context of minor pain such as a sore throat or mild headache. In many cases, ibuprofen provides a satisfactory and less expensive solution. Arcoxia is used more for more severe orthopedic or rheumatic problems. However, the decision depends of course on consultation with a doctor.

Frequently Asked Questions (FAQ)

In this section, we will expand on frequently asked questions, based on what many patients search for online.

Question 1: Does Arcoxia reduce fever?

answerA: Yes. Arcoxia has anti-inflammatory activity that can help reduce fever. However, it is not the classic fever-reducing drug (such as paracetamol). If there is a low or moderate fever, more basic medications may be sufficient. Arcoxia is mainly suitable for pain and significant inflammation.

Question 2: Is Arcoxia addictive?

answer: No. Arcoxia (Etoricoxib) does not belong to the opioid or benzodiazepine drug group. It does not have a classic addictive effect. However, uncontrolled use may lead to side effects, but not to the physical or psychological dependence typical of addictive painkillers.

Question 3: Arcoxia during pregnancy and breastfeeding – is it allowed?

answer: There are not enough studies on the use of Arcoxia during pregnancy. Most doctors will recommend avoiding it. During breastfeeding, it is also worth avoiding it, since the direct effect of Etoricoxib on the baby is unknown. In any case, it is mandatory to consult a gynecologist before taking any medication during pregnancy and breastfeeding.

Question 4: How long can Arcoxia be taken continuously?

answer: This depends on the doctor's instructions and the type of medical problem. For chronic arthritis, sometimes patients take it for weeks or months, subject to close monitoring. For acute pain (such as toothache), it is taken for only a few days. Do not use without long-term medical supervision.

Question 5: Does Arcoxia help with back pain?

answer: Yes. Arcoxia is known to be particularly effective for back pain caused by inflammation or disc degeneration. Many prefer it due to its low frequency of administration and long-lasting relief ("arcoxia for back pain"). It is recommended to verify medical compatibility with an orthopedic doctor or family doctor.

Question 6: Does Arcoxia affect the kidneys?

answer: Like other NSAIDs, Etoricoxib can also adversely affect kidney function. The risk increases with prolonged use, high doses, or when there is pre-existing kidney disease. Therefore, it is recommended to have a blood test and monitor kidney parameters if taking the drug for a long time.

Question 7: Does Arcoxia help with headaches?

answer: Arcoxia may relieve inflammatory headaches or headaches resulting from neck/upper back pain. However, for severe migraines, there are other specific medications. It is advisable to consult a doctor to adjust a more appropriate treatment.

Question 8: When should you not take Arcoxia?

answer: Arcoxia should not be taken in cases of known allergy to Etoricoxib or other NSAIDs. It should also be avoided in cases of active stomach ulcer, severe heart failure, severe liver or kidney disease. Great caution should be exercised in patients with heart disease and uncontrolled blood pressure.

Question 9: How long after Arcoxia is it permissible to drive?

answer: There is no blanket guideline. If you feel dizzy or lightheaded, it is best to avoid driving until the effects wear off. For most people, the drug does not impair driving abilities after the first few hours.

Question 10: Can Arcoxia cause anxiety?

answer: There is no extensive documentation that Arcoxia causes anxiety. However, some patients report a feeling of restlessness. These are relatively rare cases.

Question 11: Does Arcoxia cause fatigue?

answerA: Sometimes yes, but this is not a major phenomenon. If excessive fatigue or confusion is felt, it is recommended to consult with your doctor.

Question 12: Arcoxia overdose – what to do?

answer: In case of suspected overdose (taking too many tablets or accidentally taking several tablets at the same time), go to the emergency room immediately. Possible symptoms may include severe dizziness, nausea, abdominal pain, and blood pressure disorders. Prompt treatment may prevent serious damage.

Summary and a look to the future

Arcoxia (Etoricoxib) offers an effective solution for those suffering from chronic and acute inflammatory pain. It is gaining great popularity due to its high benefit and selectivity for the COX-2 enzyme. However, the increased risk of cardiovascular events cannot be ignored. On the other hand, the gastrointestinal safety profile is considered better compared to non-selective NSAIDs.

Before starting treatment with Arcoxia, it is recommended to consult a doctor and consider all risk factors, such as a history of high blood pressure, heart disease, kidney problems, and general medical condition. Common doses are 60 mg, 90 mg, and 120 mg, depending on the level of pain and inflammation. You should monitor for the appearance of side effects such as edema, increased blood pressure, or changes in kidney function.

In addition, it is important to check for interactions with other medications such as blood thinners, blood pressure medications, and even other painkillers, such as Optalgin. With regard to alcohol, it is recommended to be especially careful, as the combination may increase the risk of liver damage and gastrointestinal bleeding.

As medical research advances, we are witnessing the development of new generations of anti-inflammatory drugs. It is possible that in the future, more targeted and safer COX-2 inhibitors will be developed for the heart, liver, and kidney systems. However, for now, Arcoxia is a worthy and very useful option for some patients, especially in chronic inflammatory conditions or acute pain attacks, subject to professional supervision.

Frequently Asked Questions (FAQ) – Schema-compliant structure

question: Is Arcoxia dangerous for the heart?
answer: Arcoxia may increase the risk of cardiac events, especially with prolonged use or in high doses. Heart patients should be careful and consider alternatives.

question: Can Arcoxia be taken with blood thinners?
answer: Possible, but be careful of the increased risk of bleeding. Consult your doctor to adjust the correct treatment.

question: Does Arcoxia help with arthritis?
answerA: Yes. Arcoxia relieves osteoarthritis and rheumatoid arthritis. However, it is important to monitor for side effects.

question: Does Arcoxia reduce fever?
answerA: Yes, to some extent. However, it is not often used as a primary fever reducer.

question: Does Arcoxia affect driving ability?
answer: Most patients do not experience any harm, but some may feel dizzy. It is recommended to check personal effect before driving.

Leon Greenhouse

Prof. Leon Greenhouse is a senior psychiatrist with expertise in the neurobiology of depression and anxiety, with over 40 years of experience. He served as a professor at the Hebrew University (Emeritus), Tel Aviv University, and the University of Michigan. He has directed psychiatry departments at leading hospitals in Israel and the US (Sheba, Kfar Shaul, Eitanim, Michigan). He specializes in advanced treatments such as ECT, ketamine, DTMS, and combines psychiatric and neurological approaches to treat PTSD, OCD, schizophrenia, and ADHD. He has published over 150 scientific articles, with approximately 9,000 citations, including groundbreaking studies in the fields of TMS, CBT, and dopaminergic drugs.